Rob C Hoeben

Affiliations

Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

ORCID: 0000-0001-9443-8377

Publications (34)

A primer to gene therapy: Progress, prospects, and problems.

Journal of inherited metabolic disease

Avec: Hidde A Zittersteijn , Manuel A F V Gonçalves , Rob C Hoeben

Arming oncolytic reovirus with GM-CSF gene to enhance immunity.

Cancer gene therapy

Avec: Vera Kemp , Diana J M van den Wollenberg , Marcel G M Camps , Thorbald van Hall , Priscilla Kinderman , Nadine Pronk-van Montfoort , Rob C Hoeben

A Small Key for a Heavy Door: Genetic Therapies for the Treatment of Hemoglobinopathies.

Frontiers in genome editing

Avec: Hidde A Zittersteijn , Cornelis L Harteveld , Stefanie Klaver-Flores , Arjan C Lankester , Rob C Hoeben , Frank J T Staal , Manuel A F V Gonçalves

Adenovirus Receptor Expression in Cancer and Its Multifaceted Role in Oncolytic Adenovirus Therapy.

International journal of molecular sciences

Avec: Lobke C M Hensen , Rob C Hoeben , Selas T F Bots

Reovirus mutant jin-3 exhibits lytic and immune-stimulatory effects in preclinical human prostate cancer models.

Cancer gene therapy

Avec: Arjanneke F van de Merbel , Geertje van der Horst , Maaike H van der Mark , Selas T F Bots , Diana J M van den Wollenberg , Corrina M A de Ridder , Debra Stuurman , Tilly Aalders , Sigrun Erkens-Schulz , Nadine van Montfoort , Wouter R Karthaus , Niven Mehra , Minke Smits , Jack A Schalken , Wytske M van Weerden , Rob C Hoeben , Gabri van der Pluijm

Comparison of methods generating antibody-epitope conjugates for targeting cancer with virus-specific T cells.

Frontiers in immunology

Avec: Willemijn van der Wulp , Anna M Gram , Boris Bleijlevens , Renate S Hagedoorn , Can Araman , Robbert Q Kim , Jan Wouter Drijfhout , Paul W H I Parren , Richard G Hibbert , Rob C Hoeben , Sander I van Kasteren , Janine Schuurman , Maaike E Ressing , Mirjam H M Heemskerk

Preclinical evaluation of the gorilla-derived HAdV-B AdV-lumc007 oncolytic adenovirus 'GoraVir' for the treatment of pancreatic ductal adenocarcinoma.

Molecular oncology

Avec: Selas T F Bots , Tom J Harryvan , Christianne Groeneveldt , Priscilla Kinderman , Vera Kemp , Nadine van Montfoort , Rob C Hoeben

Reovirus Type 3 Dearing Variants Do Not Induce Necroptosis in RIPK3-Expressing Human Tumor Cell Lines.

International journal of molecular sciences

Avec: Diana J M van den Wollenberg , Vera Kemp , Martijn J W E Rabelink , Rob C Hoeben

Epstein-Barr virus nuclear antigen EBNA3A modulates IRF3-dependent IFNβ expression.

The Journal of biological chemistry

Avec: Sanne L Landman , Maaike E Ressing , Anna M Gram , Rayman T N Tjokrodirijo , Peter A van Veelen , Jacques Neefjes , Rob C Hoeben , Annemarthe G van der Veen , Ilana Berlin

Developing oncolytic viruses for clinical use: A consortium approach.

Cytokine & growth factor reviews

Avec: Vera Kemp , Martine L M Lamfers , Gabri van der Pluijm , Bernadette G van den Hoogen , Rob C Hoeben

Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?

International journal of molecular sciences

Avec: Selas T F Bots , Rob C Hoeben

Intronic

Journal of medical genetics

Avec: Remko Goossens , Marlinde L van den Boogaard , Richard J L F Lemmers , Judit Balog , Patrick J van der Vliet , Iris M Willemsen , Julie Schouten , Ignazio Maggio , Nienke van der Stoep , Rob C Hoeben , Stephen J Tapscott , Niels Geijsen , Manuel A F V Gonçalves , Sabrina Sacconi , Rabi Tawil , Silvère M van der Maarel

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.

Stem cell reports

Avec: Peter M Quinn , Thilo M Buck , Aat A Mulder , Charlotte Ohonin , C Henrique Alves , Rogier M Vos , Monika Bialecka , Tessa van Herwaarden , Elon H C van Dijk , Mays Talib , Christian Freund , Harald M M Mikkers , Rob C Hoeben , Marie-José Goumans , Camiel J F Boon , Abraham J Koster , Susana M Chuva de Sousa Lopes , Carolina R Jost , Jan Wijnholds

Protocol for Isolation, Stimulation and Functional Profiling of Primary and iPSC-derived Human NK Cells.

Bio-protocol

Avec: Janine E Melsen , Maria Themeli , Monique M van Ostaijen-Ten Dam , Els van Beelen , Gertjan Lugthart , Rob C Hoeben , Marco W Schilham , Harald M Mikkers

Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy.

Journal for immunotherapy of cancer

Avec: Christianne Groeneveldt , Priscilla Kinderman , Jordi J C van Stigt Thans , Camilla Labrie , Lisa Griffioen , Marjolein Sluijter , Diana J M van den Wollenberg , Rob C Hoeben , Joke M M den Haan , Sjoerd H van der Burg , Thorbald van Hall , Nadine van Montfoort

Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human

International journal of molecular sciences

Avec: Selas T F Bots , Vera Kemp , Iris J C Dautzenberg , Rob C Hoeben

Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy.

Cancer research communications

Avec: Christianne Groeneveldt , Jurriaan Q van Ginkel , Priscilla Kinderman , Marjolein Sluijter , Lisa Griffioen , Camilla Labrie , Diana J M van den Wollenberg , Rob C Hoeben , Sjoerd H van der Burg , Peter Ten Dijke , Lukas J A C Hawinkels , Thorbald van Hall , Nadine van Montfoort

Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures.

EBioMedicine

Avec: Theresa E Schäfer , Lisanne I Knol , Ferdinand V Haas , Anna Hartley , Sophie C S Pernickel , Attila Jády , Maximiliane S C Finkbeiner , Johannes Achberger , Stella Arelaki , Živa Modic , Katrin Schröer , Wenli Zhang , Barbara Schmidt , Philipp Schuster , Sebastian Haferkamp , Johannes Doerner , Florian Gebauer , Maximilian Ackermann , Hans-Michael Kvasnicka , Amit Kulkarni , Selas T F Bots , Vera Kemp , Lukas J A C Hawinkels , Anna R Poetsch , Rob C Hoeben , Anja Ehrhardt , Antonio Marchini , Guy Ungerechts , Claudia R Ball , Christine E Engeland

Highly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cells.

Scientific reports

Avec: Jeetindra R A Balak , Natascha de Graaf , Arnaud Zaldumbide , Ton J Rabelink , Rob C Hoeben , Eelco J P de Koning , Françoise Carlotti

Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer.

Scientific reports

Avec: Nikolas Tim Martin , Dominic Guy Roy , Samuel Tekeste Workenhe , Diana J M van den Wollenberg , Rob C Hoeben , Karen Louise Mossman , John Cameron Bell , Marie-Claude Bourgeois-Daigneault

Degenerated Cones in Cultured Human Retinas Can Successfully Be Optogenetically Reactivated.

International journal of molecular sciences

Avec: Sizar Kamar , Marcus H C Howlett , Jan Klooster , Wim de Graaff , Tamás Csikós , Martijn J W E Rabelink , Rob C Hoeben , Maarten Kamermans

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape.

Diabetes

Avec: Sofia Thomaidou , Roderick C Slieker , Arno R van der Slik , Jasper Boom , Flip Mulder , Amadeo Munoz-Garcia , Leen M 't Hart , Bobby Koeleman , Françoise Carlotti , Rob C Hoeben , Bart O Roep , Hailiang Mei , Arnaud Zaldumbide

Genomic Engineering in Human Hematopoietic Stem Cells: Hype or Hope?

Frontiers in genome editing

Avec: Stefanie Klaver-Flores , Hidde A Zittersteijn , Kirsten Canté-Barrett , Arjan Lankester , Rob C Hoeben , Manuel A F V Gonçalves , Karin Pike-Overzet , Frank J T Staal

Characterization of an immune-evading doxycycline-inducible lentiviral vector for gene therapy in the spinal cord.

Experimental neurology

Avec: F De Winter , I Francos Quijorna , E Burnside , B Hobo , R Eggers , S A Hoyng , H P Mulder , R C Hoeben , E M Muir , E J Bradbury , J Verhaagen

IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.

Diabetologia

Avec: Sofia Thomaidou , Amadeo Munoz Garcia , Sabine de Lange , Jin Gan , Arno R van der Slik , Rob C Hoeben , Bart O Roep , Françoise Carlotti , Arnaud Zaldumbide

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.

Journal for immunotherapy of cancer

Avec: Christianne Groeneveldt , Priscilla Kinderman , Diana J M van den Wollenberg , Ruben L van den Oever , Jim Middelburg , Dana A M Mustafa , Rob C Hoeben , Sjoerd H van der Burg , Thorbald van Hall , Nadine van Montfoort

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration.

Brain : a journal of neurology

Avec: Ruben Eggers , Fred de Winter , Stefan A Hoyng , Rob C Hoeben , Martijn J A Malessy , Martijn R Tannemaat , Joost Verhaagen

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1.

Diabetes

Avec: Sofia Thomaidou , Maria J L Kracht , Arno van der Slik , Sandra Laban , Eelco J de Koning , Francoise Carlotti , Rob C Hoeben , Bart O Roep , Arnaud Zaldumbide

The stability of envelope-pseudotyped lentiviral vectors.

Gene therapy

Avec: Iris J C Dautzenberg , Martijn J W E Rabelink , Rob C Hoeben

Induction of Robust Type I Interferon Levels by Oncolytic Reovirus Requires Both Viral Replication and Interferon-α/β Receptor Signaling.

Human gene therapy

Avec: Timo Oosenbrug , Diana J M van den Wollenberg , Eline W Duits , Rob C Hoeben , Maaike E Ressing

Virotherapy: The next addition to the standard of care for glioblastoma?

Cancer cell

Avec: Marike L D Broekman , Lisa Nieland , Rob C Hoeben

Immunostimulatory Profile of Cancer Cell Death by the AdV-Lumc007-Derived Oncolytic Virus 'GoraVir' in Cultured Pancreatic Cancer Cells.

Viruses

Avec: Selas T F Bots , Sanne L Landman , Martijn J W E Rabelink , Diana J M van den Wollenberg , Rob C Hoeben

Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells.

Diabetologia

Avec: René van Tienhoven , Maria J L Kracht , Arno R van der Slik , Sofia Thomaidou , Anouk H G Wolters , Ben N G Giepmans , Juan Pablo Romero Riojas , Michael S Nelson , Françoise Carlotti , Eelco J P de Koning , Rob C Hoeben , Arnaud Zaldumbide , Bart O Roep

Neutralizing antibodies impair the oncolytic efficacy of reovirus but permit effective combination with T cell-based immunotherapies.

Cancer immunology research

Avec: Christianne Groeneveldt , Priscilla Kinderman , Lisa Griffioen , Olivia Rensing , Camilla Labrie , Diana J M van den Wollenberg , Rob C Hoeben , Matthew Coffey , Houra Loghmani , Els M E Verdegaal , Marij J P Welters , Sjoerd H van der Burg , Thorbald van Hall , Nadine van Montfoort

Réseau de co-auteurs

Diana J M van den Wollenberg 10 collaborations

Selas T F Bots 7 collaborations

Vera Kemp 6 collaborations

Priscilla Kinderman 6 collaborations

Nadine van Montfoort 6 collaborations

Thorbald van Hall 5 collaborations

Christianne Groeneveldt 5 collaborations

Arnaud Zaldumbide 5 collaborations

Manuel A F V Gonçalves 4 collaborations

Martijn J W E Rabelink 4 collaborations

Sjoerd H van der Burg 4 collaborations

Françoise Carlotti 4 collaborations

Sofia Thomaidou 4 collaborations

Bart O Roep 4 collaborations

Hidde A Zittersteijn 3 collaborations

Maaike E Ressing 3 collaborations

Camilla Labrie 3 collaborations

Lisa Griffioen 3 collaborations

Arno R van der Slik 3 collaborations

Stefanie Klaver-Flores 2 collaborations

Frank J T Staal 2 collaborations

Gabri van der Pluijm 2 collaborations

Anna M Gram 2 collaborations

Sanne L Landman 2 collaborations

Marjolein Sluijter 2 collaborations

Iris J C Dautzenberg 2 collaborations

Lukas J A C Hawinkels 2 collaborations

Eelco J P de Koning 2 collaborations

Maria J L Kracht 2 collaborations

Marcel G M Camps 1 collaboration

Nadine Pronk-van Montfoort 1 collaboration

Cornelis L Harteveld 1 collaboration

Arjan C Lankester 1 collaboration

Lobke C M Hensen 1 collaboration

Arjanneke F van de Merbel 1 collaboration

Geertje van der Horst 1 collaboration

Maaike H van der Mark 1 collaboration

Corrina M A de Ridder 1 collaboration

Debra Stuurman 1 collaboration

Tilly Aalders 1 collaboration

Sigrun Erkens-Schulz 1 collaboration

Wouter R Karthaus 1 collaboration

Niven Mehra 1 collaboration

Minke Smits 1 collaboration

Jack A Schalken 1 collaboration

Wytske M van Weerden 1 collaboration

Willemijn van der Wulp 1 collaboration

Boris Bleijlevens 1 collaboration

Renate S Hagedoorn 1 collaboration

Can Araman 1 collaboration

Robbert Q Kim 1 collaboration

Jan Wouter Drijfhout 1 collaboration

Paul W H I Parren 1 collaboration

Richard G Hibbert 1 collaboration

Sander I van Kasteren 1 collaboration

Janine Schuurman 1 collaboration

Mirjam H M Heemskerk 1 collaboration

Tom J Harryvan 1 collaboration

Rayman T N Tjokrodirijo 1 collaboration

Peter A van Veelen 1 collaboration

Jacques Neefjes 1 collaboration

Annemarthe G van der Veen 1 collaboration

Ilana Berlin 1 collaboration

Martine L M Lamfers 1 collaboration

Bernadette G van den Hoogen 1 collaboration

Remko Goossens 1 collaboration

Marlinde L van den Boogaard 1 collaboration

Richard J L F Lemmers 1 collaboration

Judit Balog 1 collaboration

Patrick J van der Vliet 1 collaboration

Iris M Willemsen 1 collaboration

Julie Schouten 1 collaboration

Ignazio Maggio 1 collaboration

Nienke van der Stoep 1 collaboration

Stephen J Tapscott 1 collaboration

Niels Geijsen 1 collaboration

Sabrina Sacconi 1 collaboration

Rabi Tawil 1 collaboration

Silvère M van der Maarel 1 collaboration

Peter M Quinn 1 collaboration

Thilo M Buck 1 collaboration

Aat A Mulder 1 collaboration

Charlotte Ohonin 1 collaboration

C Henrique Alves 1 collaboration

Rogier M Vos 1 collaboration

Monika Bialecka 1 collaboration

Tessa van Herwaarden 1 collaboration

Elon H C van Dijk 1 collaboration

Mays Talib 1 collaboration

Christian Freund 1 collaboration

Harald M M Mikkers 1 collaboration

Marie-José Goumans 1 collaboration

Camiel J F Boon 1 collaboration

Abraham J Koster 1 collaboration

Susana M Chuva de Sousa Lopes 1 collaboration

Carolina R Jost 1 collaboration

Jan Wijnholds 1 collaboration

Janine E Melsen 1 collaboration

Maria Themeli 1 collaboration

Monique M van Ostaijen-Ten Dam 1 collaboration

Els van Beelen 1 collaboration

Gertjan Lugthart 1 collaboration

Marco W Schilham 1 collaboration

Harald M Mikkers 1 collaboration

Jordi J C van Stigt Thans 1 collaboration

Joke M M den Haan 1 collaboration

Jurriaan Q van Ginkel 1 collaboration

Peter Ten Dijke 1 collaboration

Theresa E Schäfer 1 collaboration

Lisanne I Knol 1 collaboration

Ferdinand V Haas 1 collaboration

Anna Hartley 1 collaboration

Sophie C S Pernickel 1 collaboration

Attila Jády 1 collaboration

Maximiliane S C Finkbeiner 1 collaboration

Johannes Achberger 1 collaboration

Stella Arelaki 1 collaboration

Živa Modic 1 collaboration

Katrin Schröer 1 collaboration

Wenli Zhang 1 collaboration

Barbara Schmidt 1 collaboration

Philipp Schuster 1 collaboration

Sebastian Haferkamp 1 collaboration

Johannes Doerner 1 collaboration

Florian Gebauer 1 collaboration

Maximilian Ackermann 1 collaboration

Hans-Michael Kvasnicka 1 collaboration

Amit Kulkarni 1 collaboration

Anna R Poetsch 1 collaboration

Anja Ehrhardt 1 collaboration

Antonio Marchini 1 collaboration

Guy Ungerechts 1 collaboration

Claudia R Ball 1 collaboration

Christine E Engeland 1 collaboration

Jeetindra R A Balak 1 collaboration

Natascha de Graaf 1 collaboration

Ton J Rabelink 1 collaboration

Nikolas Tim Martin 1 collaboration

Dominic Guy Roy 1 collaboration

Samuel Tekeste Workenhe 1 collaboration

Karen Louise Mossman 1 collaboration

John Cameron Bell 1 collaboration

Marie-Claude Bourgeois-Daigneault 1 collaboration

Sizar Kamar 1 collaboration

Marcus H C Howlett 1 collaboration

Jan Klooster 1 collaboration

Wim de Graaff 1 collaboration

Tamás Csikós 1 collaboration

Maarten Kamermans 1 collaboration

Roderick C Slieker 1 collaboration

Jasper Boom 1 collaboration

Flip Mulder 1 collaboration

Amadeo Munoz-Garcia 1 collaboration

Leen M 't Hart 1 collaboration

Bobby Koeleman 1 collaboration

Hailiang Mei 1 collaboration

Kirsten Canté-Barrett 1 collaboration

Arjan Lankester 1 collaboration

Karin Pike-Overzet 1 collaboration

F De Winter 1 collaboration

I Francos Quijorna 1 collaboration

E Burnside 1 collaboration

B Hobo 1 collaboration

R Eggers 1 collaboration

S A Hoyng 1 collaboration

H P Mulder 1 collaboration

R C Hoeben 1 collaboration

E M Muir 1 collaboration

E J Bradbury 1 collaboration

J Verhaagen 1 collaboration

Amadeo Munoz Garcia 1 collaboration

Sabine de Lange 1 collaboration

Jin Gan 1 collaboration

Ruben L van den Oever 1 collaboration

Jim Middelburg 1 collaboration

Dana A M Mustafa 1 collaboration

Ruben Eggers 1 collaboration

Fred de Winter 1 collaboration

Stefan A Hoyng 1 collaboration

Martijn J A Malessy 1 collaboration

Martijn R Tannemaat 1 collaboration

Joost Verhaagen 1 collaboration

Arno van der Slik 1 collaboration

Sandra Laban 1 collaboration

Eelco J de Koning 1 collaboration

Francoise Carlotti 1 collaboration

Timo Oosenbrug 1 collaboration

Eline W Duits 1 collaboration

Marike L D Broekman 1 collaboration

Lisa Nieland 1 collaboration

René van Tienhoven 1 collaboration

Anouk H G Wolters 1 collaboration

Ben N G Giepmans 1 collaboration

Juan Pablo Romero Riojas 1 collaboration

Michael S Nelson 1 collaboration

Olivia Rensing 1 collaboration

Matthew Coffey 1 collaboration

Houra Loghmani 1 collaboration

Els M E Verdegaal 1 collaboration

Marij J P Welters 1 collaboration